CRISPR for Cancer Therapy

We are developing RNA-guided CRISPR systems as programmable tools for selectively eliminating cancer cells. These systems can target specific mutations that are undruggable by conventional therapeutics, offering a new avenue for targeted and precise cancer treatments.

Bacterial Defence Systems

To discover new conditionally activatable enzymes and effectors, we study how bacteria defend themselves against viral infection (phages). These systems offer a rich source of diverse enzymes with unique biochemical activities that could be harnessed in medicine and biotechnology.

Gene Delivery Methods

Efficient delivery remains a key hurdle both in vivo and ex vivo. We engineer and apply state of the art gene delivery technologies to introduce nucleic acids and proteins into difficult-to-transfect cells. Our work also includes fundamental studies of intracellular trafficking and delivery efficiency to understand the rate limiting steps.